THU0420 METABOLIC SYNDROME AND TRAJECTORIES OF LOCALISED PAIN AND GENERALISED PAIN

Abstract

Background Metabolic syndrome (MetS) has been suggested as having a link to the pathophysiology of pain; however, no study has assessed whether MetS and its components are associated with localised pain and generalised pain and their courses over time. Objectives To describe the associations of MetS and its components with trajectories of localised knee pain (pain severity) and generalised pain ((number of painful sites (NPS)) in a general older population. Methods 1,099 participants from a population-based older adult cohort study were recruited at baseline. 875, 768 and 563 participants attended years 2.6, 5.1 and 10.7 follow-up, respectively. Data were collected on demographic, psychological, lifestyle and comorbidities, blood pressure, glucose, triglycerides, and high-density lipoprotein (HDL) cholesterol. MetS was defined based on the National Cholesterol Education Program-Adult Treatment Panel III criteria. Radiographic knee osteoarthritis (ROA) was assessed by X-ray. Knee pain was measured by Western Ontario and McMaster Universities Osteoarthritis Index pain questionnaire at each time-point. Presence/absence of pain at the neck, back, hands, shoulders, hips, knees and feet was collected by questionnaire at each time-point. Group-based trajectory modelling was applied to identify pain trajectories. Multi-nominal logistic regression was used for the analyses. Results Of 985 participants included in this study, 32% of participants had MetS and 60% had ROA at baseline. Three localised knee pain severity trajectories were identified: ‘Minimal pain’ (52%), ‘Mild pain’ (33%) and ‘Moderate pain’ (15%). Three NPS trajectories were identified: ‘Low NPS’ (12%), ‘Medium NPS’ (38%), and ‘High NPS’ (49%). In multivariable analysis without adjusting for central obesity, central obesity increased risk of belonging to both ‘Mild pain’ and ‘Moderate pain’ trajectories as compared to the ‘Minimal pain’ trajectory group, but MetS, hypertriglyceridemia and low HDL were only associated with ‘Moderate pain’ trajectory [relative risk (RR): 1.67-2.26, all P Conclusion MetS is predominantly associated with trajectories of localised and generalised pain through central obesity, suggesting that weight management is important in the prevention and therapy of pain over time. Disclosure of Interests None declared