THU0363 Position 97 (P97) of HLA-B, A Residue Implicated in Ankylosing Spondylitis Pathogenesis, Plays A Key Role in Cell Surface Free Heavy Chain Expression via Interactions with β2-Microglobulin

L Chen,P Bowness,H Shi,J Yuan

doi:10.1136/annrheumdis-2016-eular.3619

THU0363 Position 97 (P97) of HLA-B, A Residue Implicated in Ankylosing Spondylitis Pathogenesis, Plays A Key Role in Cell Surface Free Heavy Chain Expression via Interactions with β2-Microglobulin

L Chen, P Bowness + Show 2 more

https://doi.org/10.1136/annrheumdis-2016-eular.3619

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Journal: Annals of the Rheumatic Diseases

Publication Date: Jun 1, 2016

#Cell Surface Expression Of HLA-B #C1R Cells + Show 8 more

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Abstract

BackgroundPolymorphisms of position 97 (P97) residue in HLA-B are strongly associated with Ankylosing Spondylitis (AS).1 Position 97 residue locates in the α2 domain of HLA-B*27 and contributes to the C/F...

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