THU0302 OUTCOMES OF PREGNANCY IN BEHCET’S DISEASE

Abstract

Background: Behcet’s disease (BD) is multisystemic disease of unknown cause. The relationship between BD and pregnancy is reported in limited number of studies. Objectives: To evaluate outcomes of pregnancies in BD patients (pts). Methods: We retrospectively collected data of 22 women with BD diagnosis (according to ISGBD 1990 and ICBD 2014) and their 68 pregnancies. Pts’ mean age was 30 [26;35] yrs, disease duration 7 [2;10] yrs. Ten (45,5%) pts had severe BD according to Ch.Zouboulis classification (due to generalized uveitis, retinal vasculitis and parenchymatous CNS lesions), while other 10 (45,5%) pts had mild disease with mainly dermal-mucous manifestations, and remaining two (9%) pts had moderate disease. These patients did not receive cytotoxic therapy. Results: Sixty-eight pregnancies in 22 pts resulted in 45 live birth (4 cesarean section in 2 pts). Four patients had 11 medical abortions on request before 12 weeks of gestation, one patient - due to medical reasons (rubella on the 7th week of gestation). Seven (32%) out of 22 pts had adverse pregnancy outcomes. Five (23%) pts had 8 intrauterine deaths: one patient – 3 intrauterine deaths (4-10 weeks), two pts – 2 (10-12 weeks) and one -1 intrauterine deaths (10 weeks). Two (9%) pts had 3 miscarriages 5–10 weeks. Antiphospholipid syndrome was never detected in pts from this cohort. BD Severity and pathology of pregnancy Out of 45 babies children born by BD patients only two had relapsing aphthous stomatitis and one – congenital glaucoma (“Neurobehcet” inherited from mother). Conclusion: BD pts demonstrated high rates of adverse pregnancy outcomes. Unfavorable outcomes of pregnancy were documented in pts regardless (with all grades of) BD severity. Reference: [1] Zouboulis C., Vaiopoulos G., Macromichelakis N. et al. Onset signs, clinical course, prognosis, treatment and outcome of adult patients with Adamantiades – Behcet’s disease in Greece. Clin.Exp.Rheum.2003, 21, (suppl.30) S19-S26. Disclosure of Interests: None declared