THU0160 FEATURES OF LIPID PROFILE INDICATORS IN PATIENTS WITH RHEUMATOID ARTHRITIS IN CONNECTION WITH ARTERIAL HYPERTENSION

Abstract

Background: Patients with rheumatoid arthritis (RA) have an early development of endothelial dysfunction, an increase of the atherogenicity index (AI), and a high risk of fatal cardiovascular events. The presence of arterial hypertension (AH) in patients with RA accelerates the process of early atherogenesis and increases the risk of fatal cardiovascular events. Objectives: To evaluate the dynamics of lipid profile changes in patients with RA in combination with AH. Methods: It was examined 47 patients with RA in combination with AH (by all patients was discovered IIstage/2degree of AH). The age of the patients ranged from 18 to 72 years. Among the surveyed group dominated men (41 patients). All patients were assessed for the levels of total cholesterol (TC), low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglycerides (TG), high density lipoprotein (HDL), AI (AI = TC – HDL/LDL), antibodies to modified citrulline vimentin (anti-MCV), rheumatoid factor (RF), C-reactive protein (CRP) before treatment. All patients were also assessed for the risk of death for 10 years by the SCORE scale (> 15% - very high risk, 10-14% high, 5-3% - moderate, Results: Due to the obtained data, it can be asserted, that in patients with seronegative RA the moderate risk by SCORE was prevalent, and among seropositive RA patients– high risk. The high level of anti-MCV titres was directly corelated with the risk of the death by SCORE (p > 0,05, r = 0,64). We found that patients with RA and AH had relatively low levels of TC (5,82 ± 2,21 mmol/L) and LDL (2,82 ± 0,81 mmol/L), but the AI in these patients was 4,42 ± 0,68. It was measured the correlation between the levels of LDL and the activity of the inflammatory process DAS28, the level of CRP and the duration of RA (r = 0,56, p Conclusion: 1. Seropositivity, high activity and anamnesis of RA for more than 10 years are the factors, that are associated with high risk of fatal cardiovascular events. 2. In patients with RA in combination with AH, serum lipid levels have paradoxical ratio, resulting in lower levels of TC and LDL associated with an increased risk of cardiovascular events (”lipid paradox”). 3. The presence of high anti-MCV titres serves as a prognostically unfavorable feature of the course of RA and AH, since its association with a high risk of fatal cardiovascular events. Disclosure of Interests: None declared