THU0145 INCIDENCE, TREND AND FACTORS ASSOCIATED WITH OPPORTUNISTIC INFECTION (OI) IN PATIENTS WITH RHEUMATOID ARTHRITIS IN SPAIN. (TREND-AR STUDY)

Abstract

Background The epidemiology of hospitalizations for Opportunistic Infections (OI) in patients with rheumatoid arthritis (RA) is unknown despite an increase in RA treatments that confer risk of infection. Objectives To analyze the incidence, trend and factors associated with hospitalizations due to OI in patients with RA, in Spain, during the period between 1999 and 2015. Methods Population study based on the analysis of a national administrative database that includes a Minimum Basic Data Set (MBDS) of the income of patients with RA (ICD 9 714). Period: January 1, 1999 to December 31, 2015. The following entities were included as OI: tuberculosis (tbc), nontuberculous mycobacteria, cytomegalovirus (CMV), Epstein-Barr virus (EBV), Herpes zoster (HZ), Candidiasis, Toxoplasmosis, Pneumocystosis, Cryptococcosis, Listeriosis, Nocardiosis, Aspergillosis, Coccidioidomycosis, Histoplasmosis, Blastomycosis, Strongyloides, Leishmaniosis, Cryptoporidium, Trypanosoma cruzi, JVC and other prion viruses. These diagnoses were identified by the presence in primary and secondary diagnosis of their ICD9 codes. The population at risk was estimated through the population census of the National Institute of Statistics, with an estimated prevalence of RA of 0.5% in both sexes (0.2% in men and 0.8% in women). Crude and adjusted rates were calculated at the national level. The trend was analyzed by Generalized Linear Models (GLM) using the year variable as the analysis variable. Clinical-demographic factors associated with these infections were analyzed, using uni and multivariate logistic regression. Results Of the total of 338,343 hospital admissions in patients with RA during the 17 years of the study period, there were 4,097 (1.2%) admissions with opportunistic infection, 1591 (38.8%) in men and 2506 (61.2%) in women (p Conclusion In Spain, during the period 1999 to 2015, there has been an increase in the incidence rate of OI in patients with RA. We estimate an annual increase of 4,9%. Being male and having COPD or liver disease are associated with OI. Disclosure of Interests None declared