THU0141 A META-ANALYSIS FOR THE PREVALENCE AND RISK FACTORS OF SARCOPENIA IN RHEUMATOID ARTHRITIS

Abstract

Background:Sarcopenia is an essential issue in elderly or chronically ill subjects, and a recent surge of research on sarcopenia in patients with rheumatoid arthritis (RA) has emerged; however, the results remains controversial.Objectives:To assess the prevalence and risk factors of sarcopenia in patients with RA.Methods:We searched the studies investigating the prevalence and risk factors of sarcopenia in PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), AiritiLibrary, Chinese Electronic Periodicals Service (CEPS) and China National Knowledge Infrastructure (CNKI) Database from inception to October 5, 2019. Effects regarding prevalence and the associated risk factors were extracted and evaluated by random-effect model. Sensitivity analysis was performed for the effects.Results:After searching, twenty studies containing 3,663 RA subjects were identified, and the pooled prevalence was 35%, among which the prevalence in male and female were 39.8% and 33.3% respectively. Twelve studies reported various risk factors, and therein which had been mentioned in more than two studies were included for meta-analysis, yielding age (odds ratio [OR] 1.168, 95% confidence interval [CI] 1.032-1.322, P =0.014), female (OR 4.438, 95% CI 1.857-10.605, P < 0.001), CRP (OR 1.797, 95% CI 1.422-2.272, P < 0.001), HAQ (OR 1.756, 95% CI 1.235-2.496, P=0.002) and RF seropositivity (OR 1.935, 95% CI 1.335-2.804, P < 0.001) were significantly associated with sarcopenia in subjects with RA. There was no alteration of the results after removal any of studies in sensitivity analysis.Conclusion:Our meta-analysis demonstrated the prevalence and associated risk factors of sarcopenia in RA. More research was still warranted to clarify the relationship.