THU0120 RHEUMATIC DISEASE COMORBIDITY INDEX IMPACT ON DISEASE ACTIVITY IN PATIENTS ENROLLED IN KUWAIT REGISTRY OF RHEUMATIC DISEASES (KRRD)

Abstract

Background: Its known that the presence of certain comorbidities in patients with Rheumatoid arthritis (RA) can have an impact on the chance of achieving low disease activity (LDA). Objectives: The purpose of this study was to examine the association of different comorbidities with low disease activity index in patients enrolled in KRRD. Methods: The database of KRRD was used to include patients with RA and multiple visits. Comorbid conditions were collected at enrollment by the treating rheumatologist and modeled using the Rheumatic Disease Comorbidity index (RDCI) score, and by individual comorbid condition. Disease activity (DAS28) was assessed at routine clinic visits. Associations of comorbidity measures with disease activity over 4 years of follow up were examined using multivariable linear models. The odds of ever achieving DAS28 low disease activity ( Results: Among 1511 participants with mean age of 52 (SD 12) years, RA duration 8 (SD 6) years, 60.7% female, 77.1% RF positive, 64.6% anti-CCP positive, and 10.8% with smoking history, 1.29 had a RDCI. Hypertension (21%), diabetes mellitus (21%), hyperlipidemia (12%), cardiovascular (CV) disease (3.6%) and interstitial lung disease (ILD) (1.1%), were the most prevalent comorbidities. Select individual comorbidities, including DM, kidney disease and COPD, were more closely associated with unfavorable longitudinal disease activity, and achievement of low disease activity status. Correlation test between DAS28 and all comorbidities showed signification negative association for achieving low disease activity if the patient has history of diabetes mellitus, COPD or kidney disease. Conclusion: DM, kidney disease and COPD but not composite comorbidity scores, are associated with higher measures of disease activity and lower odds of achieving low disease activity status in RA patients enrolled in KRRD registry. Disclosure of Interests: None declared