Abstract
Background IL-6 plays a significant role in RA pathophysiology. It is considered nowadays as an important inflammation marker and it is responsible for a wide range of articular and extra-articular manifestations in RA patients. Osteocalcin is a protein (non collagenous) that can be found in the bones extracellular matrix, as well as in the circulating blood serum. This protein is a marker of bone formation and turnover. Objectives Evaluating IL-6 and osteocalcin serum levels in RA patients and their correlation with disease activity. Methods We examined 126 patients previously diagnosed with RA according to the ACR/EULAR 2010 criteria. To all patients it was measured the IL-6 serum level ( 5.1 (43 patients); group II with moderate disease activity scoring between 3.2 - 5.1 (52 patients); and group III with no disease activity scoring Results IL-6 serum level resulted elevated in patients group I (1.9±0.6pg/ml;) and group II (0.9±0.3pg/ml) and normal in patients group III (0.35±0.1pg/ml). Osteocalcin serum level resulted elevated in the three groups but with higher serum levels in patients group I and II (62±1.9ng/ml; 49.2±2.6ng/ml) and less higher serum levels in group III (44.5±1.7ng/ml). IL-6 serum level correlates best with osteocalcin serum level in patients group I and II (r=0.9). IL-6 serum level correlates with disease activity (r=1). Osteocalcin serum level correlates with disease activity in group I and II (r=0.9) but not with disease activity in group III (r=0.4). Conclusion There is a significant correlation between IL-6 serum level and disease activity according to DAS 28 in RA patients. The elevation of osteocalcin serum level correlates with disease activity in RA patients with high and moderate disease activity which is an important finding of the intense bone remodeling, whereas in patients with no disease activity bone remodeling tents to slow down. Disclosure of Interests None declared
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