THU0007 Analysis of protein acetylation and histone deacetylase expression in the synovial tissue reveals complex relationships between epigenetic regulatory mechanisms and inflammation in rheumatoid arthritis

Abstract

BackgroundEpigenetic mechanisms, including reversible acetylation and methylation of histones, play a pivotal role in regulating cellular inflammatory responses. Aberrant activity and expression of histone deacetylases (HDACs) contributes to pathology in...