ThTP1.9 The impact of patient gender on key outcomes of pancreatoduodenectomy: should gender influence patient selection?

Abstract

Abstract Aims Patients with a suspected cancer affecting the pancreatic head or periampullary region may be offered curative-intent pancreatoduodenectomy providing they are fit enough. Due to the high-risk nature of the operation and high recurrence rates, outcomes are poor. This study aimed to investigate the impact of patient gender on key short- and long-term outcomes. Methods Data were extracted from the Recurrence After Whipple’s (RAW) study, a multicentre retrospective cohort study of outcomes of pancreatoduodenectomy performed for pancreatic head malignancy (29 centres in 8 countries, n=1484). Patients were grouped by their gender and the following outcomes were compared: median length of stay (LoS), 30-day readmission, 90-day mortality, unplanned return to theatre rate, provision of nutritional support rate, five-year recurrence and five-year survival. Results Out of 1484 patients, 56% were male and 44% were female. Median LoS was thirteen days in both sexes (p=0.4). 30-day readmission (9% vs 8%, p=0.4), 90-day mortality (both 4%, p=1.0), unplanned return to theatre (both 5%, p=0.7), provision of nutritional support (42% vs 38%), five-year recurrence (60% vs 61%, p=0.8) and five-year survival (both 32%, p=0.9) rates were all similar. Conclusions In our multicentre study of patients who underwent PD for malignancy, gender did not affect the studied outcomes. Gender alone should not influence patient selection.