Abstract
Current concepts of atherogenesis based on animal and human investigations indicate prostaglandins as a key factor in atherosclerotic lesions. The plasma profiles of thromboxane B 2 (TXB 2), 6-keto-PGF 1α, PGE 2, PGF 2α, and PGA 1 were investigated by means of a sensitive radioimmunoassay technique in 40 patients with arteriosclerosis obliterans and in 30 healthy control subjects. Abnormally high levels of TXB 2 and PGE 2 (222.97 ± 320.86 pg/ml, mean ± SD, vs 20 ± 2.1 and 352.66 ± 235.54 vs 24.4 ± 3, p < 0.01) were detected in arteriosclerosis obliterans patients. The ratio between TXB 2 and 6-keto-PGF 1α was increased from 1.2 in control subjects to 6.0 in patients. In arteriosclerosis obliterans TXB 2 increased in relation to clinical manifestations and to the extension of the vascular damage. In addition, TXB 2 was positively related to serum triglyceride content ( r = 0.562, p < 0.05) and inversely related to platelet count ( r = 0.727, p < 0.001). The marked imbalance between the stable metabolites of thromboxane and prostacyclin in arteriosclerosis obliterans patients provides biologic evidence which fits well with the thrombogenic theory of atherosclerosis. These redults further support the theory that prostaglandins may be heavily involved in atherosclerosis.
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