Thrombotische Behandlung e iner experimentellen Koronarthrombose mit Streptokinase: Thrombolytic therapy of experimental coronary thrombosis with streptokinase

Abstract

Question: The influence of streptokinase on coronary thrombosis produced by vessel wall lesions by means of direct current was studied in dogs. Material and methods: The experiments were performed on 23 dogs. Without opening the thorax coronary thrombosis was induced by a steel wire electrode inserted into the right coronary artery via the common carotid artery. One, 4 and 24 hours after thrombus induction a streptokinase dose was administered which caused a maximum fibrinolytic effect of the blood of the animals. The fibrinolytic effect was estimated by determination of the thrombin time fibrinogen content and platelet count as well as by thromboelastography. The influence of streptokinase was evaluated by angiography electrocardiography and pathologic-anatomical examination. Results: After streptokinase infusion for about 3 hrs the angiography revealed a recanalization of the common carotid artery in nearly 80 per cent of the animals. During streptokinase infusion regression of the electrocardiographic alterations was found in all animals. The angiographic findingswere verified in most cases by pathologic-anatomical examinations. In the animals treated with streptokinase subepicardial and intramyocardial haemorrhages and embolization of portions of theelectrically induced coronary thrombosis were found.