Thrombotic thrombocytopenic purpura

Abstract

1. 1. The clinical and pathologic observations of two cases of thrombotic thrombocytopenic purpura are presented. 2. 2. This condition is characterized by the clinical triad of (1) hemolytic anemia; (2) thrombocytopenic purpura and (3) mental and neurologic abnormalities which may be bizarre or transient. It is not as rare as is generally considered. 3. 3. The disease is of unknown etiology although probably related to hypersensitivity and usually runs a rapid, fatal course. 4. 4. The characteristic histopathologic finding is the widespread plugging of capillaries and arterioles by hyaline lesions.