Thrombotic Thrombocytopenic Purpura in a Patient with Systemic Lupus Erythematosus

Guavita-Navarro Diana,Gallego-Cardona Laura,Cajamarca-Baron Jairo,Cubides Hector,Buitrago-Bohorquez Jhon,Arredondo Ana Maria,Guevara Diana,Escobar Alejandro

doi:10.23937/2469-5696/1410062

Guavita-Navarro Diana, Gallego-Cardona Laura + Show 6 more

Open Access

https://doi.org/10.23937/2469-5696/1410062

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Abstract

Thrombotic microangiopathy is a group of syndromes characterized by thrombocytopenia, microangiopathic hemolytic anemia, and acute organ dysfunction secondary to ischemia. It includes a group of diseases such as thrombotic thrombocytopenic purpura. They can be primary or secondary to multiple pathologies, including autoimmune diseases such as systemic lupus erythematosus. These associations are important from the clinical point of view, as they have more severe presentations, high relapse rates, and in some cases poor response to conventional treatment.

Highlights

Thrombotic microangiopathy (TMA) is a group of syndromes that includes Thrombotic thrombocytopenic purpura (TTP), which is conditioned by a deficiency of the metalloproteinase ADAMTS13; It can be primary or secondary, and within etiologies of the latter, autoimmune diseases such as Systemic lupus erythematosus (SLE) [1,2].We present the case of a patient with systemic lupus erythematosus presenting with thrombotic thrombocytopenic purpura
We present the case of a patient with thrombotic microangiopathy associated with SLE with characteristics of a classic thrombotic purple thrombocytopenia
TMA is a syndrome characterized by microangiopathic hemolytic anemia associated with thrombocytopenia and ischemic injury secondary to arteriolar and capillary thrombosis of different organs

Summary

Introduction

Thrombotic microangiopathy (TMA) is a group of syndromes that includes Thrombotic thrombocytopenic purpura (TTP), which is conditioned by a deficiency of the metalloproteinase ADAMTS13 (a metalloproteinase similar to disintegrin and with thrombospondin type 1 motif # 13); It can be primary or secondary, and within etiologies of the latter, autoimmune diseases such as Systemic lupus erythematosus (SLE) [1,2].We present the case of a patient with systemic lupus erythematosus presenting with thrombotic thrombocytopenic purpura. Thrombotic microangiopathy is a group of syndromes characterized by thrombocytopenia, microangiopathic hemolytic anemia, and acute organ dysfunction secondary to ischemia. They can be primary or secondary to multiple pathologies, including autoimmune diseases such as systemic lupus erythematosus.

Results

Conclusion