Abstract
We performed a retrospective case control study to evaluate the histological characteristics of SARS-CoV-2 positive pediatric patients undergoing laparoscopic exploration for acute abdomen symptoms.To our knowledge this is the first study that analyzes histopathological characteristics of abdominal tissues in SARS-CoV-2 children. We enrolled eight Multisystem Inflammatory Syndrome in Children (MIS-C) patients and four SARS-CoV-2 positive patients underwent intestinal resection vs thirty-six control appendectomies from two pediatric tertiary referral centers between March 2020 and July 2021.Surgical resection samples were evaluated on several histological sections focusing on general inflammatory pattern and degree of inflammation.Peculiar histological features (endotheliitis and vascular thrombosis) were semi-quantitatively scored respectively in capillary, veins and arteries. All SARS-CoV-2 related surgical samples showed thrombotic patterns. Those patterns were significantly less frequent in SARS-CoV-2 negative appendectomies (p: 0.004). The semi-quantitatively score of thrombosis was significantly higher (p:0.002) in patients with SARS-CoV-2 related procedures. Our results showed that SARS-CoV-2 can cause thrombotic damage in abdominal tissues both in the acute phase of the infection (SARS-CoV-2 related appendectomies) and secondary to cytokine storm (MIS-C).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Journal of pediatric gastroenterology and nutrition
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.