Abstract
Thrombospondin-related adhesive protein (TRAP) plays a part in malaria sporozoite recognition and entry into host hepatocytes.1,2 Little is known about how this molecule, mainly localised in the parasite micronemes, contributes to sporozoite invasion.3 The presence of conserved adhesive motifs within the aminoacid sequence of TRAP suggested that this molecule could interact directly with ligands on the surface of host cells.4 We observed that air-dried Plasmodium berghei sporozoites, while being processed for immuno-fluorescence, leave a trail of TRAP immunoreactive material on the microscope slide, suggesting that TRAP was released during parasite movement.
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