Abstract
The aim of the present study was to study the expression and relationship of potential angiogenic factors. Paraffin-embedded tumour sections from 261 breast cancer patients were stained immunohistochemically for thrombospondin (TSP-1) expression. p53 status was previously determined by cDNA-based sequencing, and vascular endothelial growth factor (VEGF) protein expression had been previously analysed using an immunoassay. 241 cancers (92%) had detectable levels of TSP-1. No associations between TSP-1 and p53 status or VEGF were found. No correlations between TSP-1 and relapse-free ( P = 0.3), breast cancer-corrected ( P = 0.2) or overall survival ( P = 0.5) were found. A correlation was found for patients with p53 mutations, but negative p53 expression, with higher VEGF levels ( P = 0.009), but there was no correlation between this p53 group and those with low TSP-1 levels ( P = 0.2). In conclusion, TSP-1 expression was not prognostic and was not associated with neither p53-status or VEGF expression.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
