Abstract
Thrombomodulin (TM) is a transmembrane glycoprotein expressed on the surface of endothelial cells and acts as a cofactor for thrombin. The human TM protein is composed of five domains (Figure 1) (1). Thrombin binding to TM activates protein C to initiate the anticoagulant pathway. Although previous studies revealed the anticoagulant effects of TM, recent studies have suggested that TM, especially its lectin-like domain (TMD1), seems to play an important role in anti-inflammatory activity. This article is protected by copyright. All rights reserved.
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