Thrombolysis in Pediatric Population from the KID Database (S03.005)

Abstract

Objective: To assess safety outcomes associated with thrombolysis in children in a large sample. Background Thrombolysis for acute ischemic stroke (AIS) in children is yet to be proven efficacious. There is limited information about safety in large pediatric samples. Design/Methods: A cohort of children with AIS was identified from the Kids9 Inpatient Database for the years 1998 to 2009. AIS identified by the clinical classification software codes (109 and 110). Multivariate logistic regression analyses were used to assess covariates associated with hospital mortality and intracerebral hemorrhage (ICH). Results: In this analysis, 9367 children were admitted with the diagnosis of AIS; only 75 (0.8%) had received thrombolysis. The mean age of the treated children was older than the rest of the cohort (12.88 ± 7.5 vs. 8.18 ± 7.5; P Conclusions: Thrombolysis for AIS is infrequently utilized in children. However, the risk of ICH is as low as those reported in adult population. Thrombolysis is associated with ICH but was not predictive of higher mortality. Disclosure: Dr. Alshekhlee has nothing to disclose. Dr. Storkan has nothing to disclose. Dr. Kaushal has nothing to disclose. Dr. Mehta has nothing to disclose. Dr. Feen has nothing to disclose. Dr. Cruz-Flores has received personal compensation for activities with Quintiles, Roche Diagnostics Corporation, and Axio. Dr. Cruz- Flores has received research support from Coaxia.