Abstract
8524 Background: Adults with malignancy are at increased risk for thromboembolic events (TEE). However, data on TEE in pediatric patients with cancer are limited. Methods: To ascertain the risk and clinical features of TEE in pediatric sarcoma patients, we reviewed records on 119 consecutive patients with sarcoma treated from 10/80 to 07/02. Results: Median patient age was 18 years (range 4–32). Twenty-two TEE were diagnosed in 18/119 (15.1%) patients. Incidence by diagnosis was Ewing's sarcoma 7/61 (11.5%), osteogenic sarcoma 2/20 (10%), rhabdomyosarcoma 4/24 (16.7%) and other sarcomas 5/14 (35.7%). TEE developed in 12/51 (23.5%) patients with metastases at presentation vs. 6/68 (8.8%) with local disease (p=0.028). Thromboses were detected at presentation in 13/22 (59.1%), during the initial treatment cycle in 4/22 (18.2%), and at recurrence in 5/22 (22.7%). Ten (45.5%) events were asymptomatic (detected on routine imaging or autopsy). Sites of thromboses were deep veins of the extremities 10/22 (45.5%),...
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