Thrombocytosis Associated with Low-Molecular-Weight Heparin

Abstract

Letters1 May 1997Thrombocytosis Associated with Low-Molecular-Weight HeparinDavid A. Rizzieri, MD and Jan P. Gockerman, MDDavid A. Rizzieri, MDDuke University Medical Center, Durham, NC 27710Search for more papers by this author and Jan P. Gockerman, MDDuke University Medical Center, Durham, NC 27710Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-9-199705010-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Williams's interest in our report of thrombocytosis associated with the use of enoxaparin in a patient with adrenocortical carcinoma. We argue that the patient's clinical course is not consistent with other known causes. Thrombocytosis in association with splenectomy is first noted within 2 weeks after the procedure and typically resolves over a few months, although the reactive process occasionally takes years to resolve [1, 2]. As Dr. Williams notes, neoplastic processes may also be associated with severe thrombocytosis, usually because of increased platelet production [2, 3]. Our patient's platelet counts were normal, about 250 000 ...