Abstract
We reviewed the prevalence of thrombocytosis (platelet count ≥400,000/μL) and its association with outcome in 135 consecutive endometrial carcinoma patients and compared the platelet count with other prognostic factors. Nineteen of 135 patients (14%) had thrombocytosis. Thrombocytosis was significantly more frequent in advanced disease (stage II–IV), unfavorable grade (G2 and G3), deep myometrial invasion, and lymph–vascular space invasion. The overall 5-year survival rate was 92%. The 5-year survival rate of the 19 patients with thrombocytosis was significantly worse than that of the patients without thrombocytosis (61 vs 96%,P< 0.0001). The recurrence rate was significantly higher in patients with thrombocytosis than in those with a platelet count <400,000/μL (7 vs 32%,P< 0.005). In a multivariate analysis, thrombocytosis continued to be a predictor of worse prognosis. In conclusion, we found thrombocytosis to be a prognostic factor for survival in patients with endometrial carcinoma.
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