Abstract
Dyschromatosis universalis hereditaria (DUH) is an extremely rare genodermatosis, characterised by hyperand hypo-pigmented macules forming a reticulate pattern. We describe a patient with features of DUH. DOI: http://dx.doi.org/10.4038/cmj.v57i3.4705 Ceylon Medical Journal 2012; 57 : 124-125
Highlights
Dyschromatosis universalis hereditaria (DUH) is an extremely rare genodermatosis, characterised by hyperand hypo-pigmented macules forming a reticulate pattern
Two major types of DUH have been described, based on distribution of lesions: dyschromatosis universalis hereditaria (DUH), in which a mixture of hyper and hypopigmented macules occur all over the body presenting as a generalised leukomelanoderma with relative sparing of the face, palms, and soles and dyschromatosis symmetrica hereditaria (DSH), which is characterised by a symmetrical distribution of hyperpigmented and hypopigmented macules on the extremities [1, 2]
It has been suggested that DUH is a disorder of the number of melanocytes
Summary
Dyschromatosis universalis hereditaria (DUH) is an extremely rare genodermatosis, characterised by hyperand hypo-pigmented macules forming a reticulate pattern. A 14-year old boy presented to causality medical ward with history of left side chest pain and asymptomatic progressive mottled pigmentation over the trunk and limbs, which had been noted since birth and had become more noticeable with age. Physical examination showed numerous asymptomatic, generalised hyperpigmented macules of 0.5 cm interspersed with spotty hypopigmented macules. The lesions were denser on the limbs (Figure1) than on the trunk (Figure 2).
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