Thrombocytopenia during pregnancy and its outcome- A prospective study

Abstract

Thrombocytopenia is the second most common haematological finding in pregnancy after anaemia. Thrombocytopenia is defined as decrease in platelet count < 1,50,000/µL. The physiological thrombocytopenia of pregnancy is mild and has no adverse effects on mother and foetus whereas thrombocytopenia associated with medical conditions can have serious maternal-foetal consequences and needs specific monitoring and appropriate management. : The aims of the study were to evaluate causes of thrombocytopenia in pregnancy and to study clinical profile, maternal and perinatal outcome in thrombocytopenic antenatal patients after 28 weeks.: Aprospective study was conducted in department of Obstetrics and Gynaecology and department of Pathology at Government Medical College and Rajendra Hospital, Patiala.100 antenatal females were included in the study with platelet count <1,50,000/µL and period of gestation more than 28 weeks. The subjects were investigated after detailed history and examination. Maternal and foetal outcomes were observed in all cases.Out of 100 subjects with thrombocytopenia, 33% had gestational thrombocytopenia, which was the most common cause; followed by preeclampsia/eclampsia (24%). 18% subjects had severe thrombocytopenia. Complications were seen in the form of HELLP (6%), ICU admission (3%), PPH (3%), Puerperal sepsis (1%). Maternal thrombocytopenia due to medical causes needs strict observation and timely intervention for favourable maternal and perinatal outcomes.