Abstract
BackgroundThrombocytopenia (TP) has been shown to be an independent predictor of mortality in the intensive care unit (ICU) patients. Studies are lacking in the neurological ICU (NICU) population. The aim was to evaluate the incidence of TP in NICU and the relationship between TP and outcomes.MethodsWe conducted a retrospective multicenter study of prospectively collected data of all patients admitted to the NICU between 2014 and 2015 from a large database (eICU Collaborative Research Database). The main exposure was TP at admission and TP developed during NICU stay. Multivariable logistic regression and Cox proportional hazard models were used to evaluate the relationship of TP at admission and platelet course with hospital mortality. The primary outcome was hospital mortality.Results7450 patients in NICU from 17 hospitals were included. Hospital mortality was 9%. TP at admission was present in 20% of patients, TP developed during NICU stay was present in 13.2% of patients. TP at admission was not associated with hospital mortality after adjusting for confounders (OR 1.14 [95% CI 0.92–1.41, p = 0.237]). Hospital mortality of continuous TP during NICU stay was 15% while hospital mortality of recovery from TP at admission was 6% (p < 0.001). Patients with TP developed during NICU stay had higher odds ratio for hospital mortality (OR 1.65 [95% CI 1.3–2.09, p < 0.001]).ConclusionsThrombocytopenia is common in NICU and patients who have thrombocytopenia not resolving have increased mortality. Patients’ recovery from thrombocytopenia may predict a good prognosis.
Highlights
Thrombocytopenia (TP) has been shown to be an independent predictor of mortality in the intensive care unit (ICU) patients
To determine the prevalence and significance of TP in neurological ICU (NICU), we studied patients admitted to multicenter NICUs
The main objectives of the present study were to investigate the incidence of TP in NICU and the relationship of TP at admission and platelet course with hospital mortality in patients admitted in NICU
Summary
Thrombocytopenia (TP) has been shown to be an independent predictor of mortality in the intensive care unit (ICU) patients. The aim was to evaluate the incidence of TP in NICU and the relationship between TP and outcomes. Thrombocytopenia (TP) is one of the most common problems in different kinds of intensive care units (ICUs), such as medical ICU, surgical ICU, medical/surgical ICD, pediatric ICU, neonatal ICU, coronary ICU, cardiac surgical ICU, and has been considered to play an TP has been found associated with increased bleeding episodes and increased transfusion requirements of platelets, fresh frozen plasma, and red blood cells and. Zhou et al BMC Neurology (2020) 20:220 has been associated with prolonged ICU and hospital stays and increased mortality in critically ill patients [4,5,6,7,8,9]. The relationship between TP and outcomes in neurological critically ill patients is still unknown.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
