Abstract
Cytolysis test in agarose gel was applied to study surface antigens of platelets. By means of rabbit antisera to nucleated cells and/or erythrocytes, species-specific antigens were demonstrated on platelets of various species. In studying reactions of human platelets with rabbit antisera, it was found that species antigens shared by nucleated cells and erythrocytes play a major role in thrombocytolysis. Evidence was also presented that human platelets contain surface antigens specific for platelets. Forssman antigen was detected on platelets of Forssman-positive species guinea pig, hamster and chicken. Heterophile antigen (Paul-Bunnell antigen) was demonstrated on bovine and sheep platelets. Lytic titers of most infectious mononucleosis sera were considerably higher against bovine than against sheep platelets. Results obtained in preliminary studies indicated that thrombocytolysis in gel may be used for detection of human alloantigens on platelets.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International archives of allergy and applied immunology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
