Thrombocytic activity in patients with arterial hypertension associated with metabolic syndrome

Abstract

This work was aimed to elucidate the level of in vitro and in vivo aggregation activity of platelets and the functional significance of individual mechanisms of its regulation in patients with grade III arterial hypertension and metabolic syndrome. The study included 29 adult patients (15 men and 14 women) and 25 clinically healthy subjects of similar age. Biochemical, hematological and statistical methods were used. Marked dyslipidemia was associated with active lipid peroxidation. Plasma thromboxane B2 level was increased by 84,8% while 6-ketoprostaglandin F1α level was decreased by 17,9% and the total amount of NO metabolites by 28,7%. The degree of platelet aggregation and their aggregation with collagen 25,0 and 27,5% lower than the respective control values while the respective indices of their aggregation with ristomycin were 25,7 and 46,4% higher. The degree of platelet aggregation and their aggregation with ADP inducer were 25,7 and 58,4% higher than in control while the platelet-discocyte levels were reduced to 48,6 ± 0,4%. The sum of active platelet forms reached 51,4 ± 0,12% vs 17,9 ± 0,09% in control was, the number of small and large aggregates 18,6 ± 0,08 and 5,4 ± 0,04 per 1000 free platelets respectively vs 2,9 ± 0,06 и 0,2 ± 0,06 in control. Excess platelet activity in the patients was due to their enhanced adhesive and aggregative potential and reduced ability to disaggregate. The most important causs of thrombocytopathy was AH, negative changes in plasma lipid composition, and enhanced lipid peroxidation.