THROMBOCYTE INDICES RELATION WITH GESTATIONAL HYPERTENSIVE DISORDERS

Abstract

The aim of this study to evaluate relationship between thrombocyte indices, Red cell distribution width (RDW) and gestational hypertensive disorders. This study is a retrospective cross sectional study performed between 2009 - 2019.Total 583 pregnant women were included in this study; 123 severe preeclampsia (PE), 175 mild-PE, 73 gestational hypertension (GH), 41 chronic hypertension and 171 healthy pregnant women (control group). Statistical Package for Social Science version 23.0 is used for statistical analysis. Kolmogorov-Smirnov, Anova, Kruskal-Wallis and Mann Whitney U tests are used for interpretation of data. Statistical significance is considered if p < 0.05. Mean age and number of pregancies were indifferent among five groups. Mean Platelet Volume (MPV) was significantly higher in severe-PE group (p<0.001) and insignificantly different among mild-PE, GH, chronic hypertension and control groups (p=0.116) . Platelet count (PC) was found significantly lower in severe-PE group (p=0.01) and found indifferent among mild-PE, GH, chronic hypertension and control groups (p=0.110). RDW was found significantly higher in severe-PE group than other groups (p=0.01)and significantly higher in mild-PE group than GH, chronic hypertension and control groups (p=0.01) but insignificantly different among GH, chronic hypertension and control groups (p=0.501). Platelet distribution width (PDW) was found significantly lower in control group than other groups (p<0.001) and found indifferent among mild-PE, GH, chronic hypertension and severe-PE groups (p=0.621). Neutrophil lymphocyte ratio (NLR), hemoglobin, Plateletcrit and Platelet lymphocyte ratio (PLR) were found unchanged among the groups. MPV, RDW, PDW, NLR, PC, Plateletcrit and PLR were indifferent among GH and chronic hypertension groups. MPV and RDW were found higher and PC was found lower in severe-PE. RDW levels elevation was found higher in accordance with the severity of preeclampsia. PDW was found higher in gestational hypertensive disorders than healthy pregnant women.