Thrombocyte Functions in Pregnant Women with Gestational Diabetes Mellitus

Abstract

Objective: We have aimed to show the changes of number, morphology and functions of platelets in presence of gestational diabetes mellitus comparing to patients that are not diagnosed with gestational diabetes mellitus in our study. Methodology: The 928 cases in 24th to 28th weeks of gestation followed regularly in the same clinic were included in the study. Mean platelet volume, platelet distribution width and plateletcrit values of cases that are diagnosed with gestational diabetes mellitus according to American Diabetes Association criteria and that are not diagnosed with gestational diabetes mellitus were compared to evaluate the platelet count, morphology, functions and activity. Results: Platelet count and plateletcrit values of cases diagnosed with gestational diabetes mellitus were significantly higher than those that were not diagnosed with gestational diabetes mellitus. No difference between mean platelet volume and platelet distribution width values of cases diagnosed with gestational diabetes mellitus and not diagnosed with gestational diabetes mellitus was found. Conclusion: 75 gm oral glucose tolerance test to prevent false negative results and evaluation of platelet count, function and activity for cases that are diagnosed with gestational diabetes mellitus could contribute importantly to predict and take necessary precautions for possible atherosclerotic vascular and end-organ damage.