Year-end Sale % OFF 
Abstract
Reference interval for thrombin-antithrombin complex (TAT) level was determined using an in-house TAT measurement device, and its validity for diagnosis of disseminated intravascular coagulation (DIC) was evaluated in dogs. One hundred and two clinically healthy dogs and 247 diseased dogs with conditions that potentially caused DIC were recruited in the study. Six diagnostic testing for DIC were evaluated in diseased dogs and the diseased dogs were categorized into five groups depending on abnormal findings. TAT was measured in all study animals and between-group differences were evaluated. TAT level was positively associated with severity of DIC. There were no significant differences in TAT levels among clinically healthy dogs, diseased dogs without any abnormal finding and diseased dogs with one abnormal finding in the DIC diagnostic testing. TAT levels in groups with two or more abnormal findings were significantly higher than clinically healthy dogs. Reference interval of TAT level for clinically healthy dogs was ≤ 0.25 ng/ml. Validity of using TAT for early detection of DIC was evaluated. In-house TAT measurement was suggested to be a clinically relevant and useful tool for early detection of canine DIC.
Highlights
disseminated intravascular coagulation (DIC) is a common clinical condition caused by numerous diseases in dogs seen in veterinary practice
One study defined DIC as a condition characterized by abnormal findings in four out of six parameters including platelet count, prothrombin time (PT), fibrinogen-fibrin degradation product (FDP), activated partial thromboplastin time (APTT), plasma fibrinogen level, fibrinogen fibrin degradation product (FDP), and antithrombin activity (AT) [3]
Dogs admitted with clinical conditions which received coagulation-fibrinolysis tests were included as cases and were further divided into five groups depending on the number of abnormal findings observed in coagulation-fibrinolysis tests
Summary
DIC is a common clinical condition caused by numerous diseases in dogs seen in veterinary practice. Prognosis was generally poor causing high mortality once dogs develop DIC[1, 2]. Validated early detection of DIC is not available. Diagnostic criteria for DIC in dogs are not yet fully developed or discussed in veterinary literature. One study defined DIC as a condition characterized by abnormal findings in four out of six parameters including platelet count, prothrombin time (PT), fibrinogen-fibrin degradation product (FDP), activated partial thromboplastin time (APTT), plasma fibrinogen level, fibrinogen fibrin degradation product (FDP), and antithrombin activity (AT) [3]. Another study defined DIC as a condition
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
