Abstract
The relationship of a thrombin-induced burst in O 2 consumption to lipid peroxidation in washed human platelets was investigated by measuring malonyldialdehyde, a by-product of endoperoxide degradation in platelets. The ratio of O 2 consumed to malonyldialdehyde produced was approximately 7:1. Acetylsalicylate blocked the formation of malonyldialdehyde completely and partially inhibited the O 2 burst induced by thrombin. 5,8,11,14-Eicosatetraynoic acid inhibited the O 2 burst as well as the malonyldialdehyde formation completely. The release of [ 14C]serotonin was not affected by either inhibitor.
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