Threshold value of Anti Mullerian Hormone (AMH) and its correlation with other related hormones in Polycystic Ovarian Disease

Abstract

Background: Polycystic ovarian disease (PCOD) is the commonest endocrine disorder affecting women at reproductive age. As a complex multisystem disorder, its background can be confusing to understand. The key feature is an increased production of AMH by antral follicles. Aim: The aim of the present study was to assess the threshold value of serum AMH in PCOD and its correlation with other related hormones such as FSH, LH and Prolactin. Materials and Methods: Serum AMH, FSH, LH and Prolactin in all subject (PCOD and Non PCOD groups) were estimated using Cobas-e-411analyser. The results analyzed statistically by Using Z-test (p value <0.05 considered as significant), Correlation test and ROC analysis. Result: Serum AMH and LH shown significant increase level in PCOD groups compared to Non PCOD groups (p value=0.00, 0.001 respectively). Serum FSH and Prolactin have shown no much significant variation between the two groups (p value=0.75, 0.8 respectively). Threshold values of serum AMH and LH was observed as 8.47 ng/ml and 15.57 mIU/ml respectively. Additionally, serum AMH and LH has shown the strong positive correlation in PCOD group; no other parameters shown any correlation in both groups. Conclusion: Serum AMH level estimation can be considered as a better choice for diagnosis of PCOD especially in the situation wherever ultrasonography examination is not convenient to conduct