Abstract
Abstract Measurements were made of the appearance time of fibrinolytic activity in plasma during urokinase (UK) infusion at various speeds to the rabbits. There was no observable fibrinolytic activity at a low infusion speed, but fibrinolytic activity did appear when the infusion speed was high. The results obtained indicated that threshold phenomena governed the appearance of fibrinolytic activity in the plasma, with a critical UK infusion speed of about 2,500 units/min. For infusions below this speed, even the administration of 300,000 units of UK failed to induce observable fibrinolytic activity in the plasma, reflecting the dynamic participation of the inhibition system of blood fibrinolysis under these conditions.
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