Abstract
Threshold of Toxicological Concern (TTC) is a tool that aids assessment of human health risks from exposure to low levels of chemicals in the diet, when specific toxicity data are not available. It provides threshold toxicity values for oral dosing in structural categories (Cramer classes 1, 2 and 3 (1800, 540 and 90 ug/day1.8, 2 0.54 and 3 0.09 mg/d ). Our aim is to adapt the TTC concept to cosmetics applied to the skin and address the importance of differences in bioavailability between oral and dermal exposures.This poster describes a decision tree approach for estimating systemic availibility following dermal exposure, allowing application of oral TTC. .... Objectives
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