Threshold limit values of the antiviral drug interferon inducer amixin in the air of the working area and in the atmospheric air of urban and rural settlements

Abstract

Introduction. Amiksin (tiloron) is a low molecular weight inducer of interferon, antiviral and immunomodulatory agent, used for the treatment and prevention of viral diseases, shown the effectiveness of including amixin in the complex therapy of SARS-CoV-2 infection (COVID-19) mild and moderate severity. Materials and methods. Experimental studies to determine the parameters of amixin toxicometry were carried out using mice, rats, rabbits and guinea pigs. The substance was administered into the stomach, intraperitoneally, into the conjunctival sac of the eye, on the skin, intradermal and inhalation. Results. It is shown that amixin belongs to the 3rd hazard class (moderately hazardous substances) when injected into the stomach according to GOST 12.1.007-76: DL50 for male mice - 500 mg/kg, for female mice - 760 mg/kg; low toxicity when injected into the abdominal cavity, DL50 for male mice - 150 mg/kg. Amiksin has a weak irritant effect on the mucous membranes of the eyes, does not irritate the skin, has a skin-resorptive effect and functional cumulative activity. The threshold for acute inhalation exposure to amixin is set at 16,2 mg/m3 according to the effect on the functional state of the liver and kidneys. Limitations. When developing and substantiating the hygienic standards for amixin in the air, various ways of the substance entering the body of several animal species in representative groups were studied. Conclusion. For amixin aerosol, hygienic standards have been approved - 0,4 mg/m3 in the air of the working area and 0,01 mg/m3 in the atmospheric air.