Abstract
Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D [25(OH)D] and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency. Methods: Serum samples were selected from the biological samples’ bank of the Chinese Chronic Diseases and Nutrition Survey (CCDNS) 2015. The serum 25(OH)D concentration was determined by liquid chromatography tandem mass spectrometry and the serum PTH was determined by electronic chemiluminescence. Simple linear and partial correlation analysis, locally weighted regression smooth scatterplot (LOESS), nonlinear least squares estimation (NLS), and segmented regression (SR) were utilized to estimate the relationship of 25(OH)D and PTH, and to determine the threshold of 25(OH)D. Results: A total of 1568 serum samples of 25(OH)D concentration and PTH concentration were analyzed. A significant inverse relationship between 25(OH)D and PTH concentration was observed below 15.25 (14.22–16.28) ng/mL, and PTH decreased slowly with the increase of 25(OH)D above 16.75 (15.43–18.06) ng/mL after adjusting by age, latitude, city type, season, corrected calcium, and phosphorus. A very short plateau of PTH was found at 15.25 ng/mL and 16.75 ng/mL in terms of 25(OH)D according to LOESS, NLS, and SR. Conclusions: The serum 25(OH)D was negatively correlated with the serum PTH. The threshold of VitD sufficiency was found in the range of 14.22–18.06 ng/mL in terms of serum 25(OH)D concentration for Chinese childbearing women aged 18–44 years old.
Highlights
Vitamin D (VitD) is one of the essential micronutrients in the human body
VitD can stimulate the synthesis of osteopontin and alkaline phosphatase in osteoblasts and inhibit the apoptosis of osteoblasts, which is beneficial to bone formation [1]
The serum 25(OH)D concentration and parathyroid hormone (PTH) concentration of 1568 blood samples of Chinese childbearing women aged 18–44 y were included in this study
Summary
Vitamin D (VitD) is one of the essential micronutrients in the human body. VitD can stimulate the synthesis of osteopontin and alkaline phosphatase in osteoblasts and inhibit the apoptosis of osteoblasts, which is beneficial to bone formation [1]. 25-hydroxyvitamin D [25(OH)D] is the main circulation form of VitD in blood with a longer half-life of 2–3 weeks than that of 1,25(OH) D and 24,25(OH) D [3,4]. It is recognized as a reliable indicator for evaluating VitD status in the human body [5]. 25-hydroxyvitamin D [25(OH)D] and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency. A significant inverse relationship between 25(OH)D and PTH concentration was observed below 15.25
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