Three-dimensional printing with biomaterials in craniofacial and dental tissue engineering.

Wen Liao,Yang Yao,Yu Du,Qiuchan Xiong,Kaijuan Wangrao,Lin Xu

doi:10.7717/peerj.7271

Abstract

With the development of technology, tissue engineering (TE) has been widely applied in the medical field. In recent years, due to its accuracy and the demands of solid freeform fabrication in TE, three-dimensional printing, also known as additive manufacturing (AM), has been applied for biological scaffold fabrication in craniofacial and dental regeneration. In this review, we have compared several types of AM techniques and summarized their advantages and limitations. The range of printable materials used in craniofacial and dental tissue includes all the biomaterials. Thus, basic and clinical studies were discussed in this review to present the application of AM techniques in craniofacial and dental tissue and their advances during these years, which might provide information for further AM studies in craniofacial and dental TE.

Highlights

The development of tissue engineering (TE) and regeneration constitutes a new platform for translational medical research
21 days The results show that osteoclast-like cells were able to resorb calcium phosphate surfaces consisting of granules
This study suggested that 3D printing scaffolds, marrow clots (MC) could provide a promising candidate for cartilage regeneration (Yao et al, 2015)

Summary

INTRODUCTION

The development of tissue engineering (TE) and regeneration constitutes a new platform for translational medical research It has already been an important kind of therapeutic method in craniofacial and dental field, such as trauma, skeletal disease, wound surgery and periodontal disease (Rai et al, 2017). It helps researchers to meet the demands of solid freeform fabrication in TE, too (Warren et al, 2003; Obregon et al, 2015) It has unique advantages in fabrication of patient-specific scaffolds with multiple materials. Materials with live cells were used, making it possible to construct organ and tissue using AM (Mannoor et al, 2013) Another hots spot of study in the field of tissue engineering combined with material manufacturing methods is electrospinning.

SURVEY METHODOLOGY

Findings

CONCLUSIONS