Three-Dimensional Photoacoustic Computed Tomography: Imaging Models and Reconstruction Algorithms

Abstract

OF THE DISSERTATION Three-Dimensional Photoacoustic Computed Tomography: Imaging Models and Reconstruction Algorithms by Kun Wang DOCTOR OF PHILOSOPHY in Biomedical Engineering Washington University in St. Louis, December 2012 Research Advisor: Professor Mark Anastasio Photoacoustic computed tomography (PACT), also known as optoacoustic tomography, is a rapidly emerging imaging modality that holds great promise for a wide range of biomedical imaging applications. Much effort has been devoted to the investigation of imaging physics and the optimization of experimental designs. Meanwhile, a variety of image reconstruction algorithms have been developed for the purpose of computed tomography. Most of these algorithms assume full knowledge of the acoustic pressure function on a measurement surface that either encloses the object or extends to infinity, which poses many difficulties for practical applications. To overcome these limitations, iterative image reconstruction algorithms have been actively investigated. However, little work has been conducted on imaging models that incorporate the characteristics of data acquisition systems. Moreover, when applying to experimental data, most studies simplify the inherent three-dimensional wave propagation as two-dimensional imaging models by introducing heuristic assumptions on the