Abstract
A custom made dermatological Jones matrix optical coherence tomography (JM-OCT) is presented. It uses a passive-polarization-delay component based swept-source JM-OCT configuration, but is specially designed for in vivo human skin measurement. The center wavelength of its probe beam is 1310 nm and the A-line rate is 49.6 kHz. The JM-OCT is capable of simultaneously providing birefringence (local retardation) tomography, degree-of-polarization-uniformity tomography, complex-correlation-based optical coherence angiography, and conventional scattering OCT. To evaluate the performance of this JM-OCT, we measured in vivo human skin at several locations. Using the four kinds of OCT contrasts, the morphological characteristics and optical properties of different skin types were visualized.
Highlights
Optical coherence tomography (OCT) is a noninvasive, high resolution, and fast imaging modality that is capable of visualizing the internal micro-structures of in vivo tissue [1]
Futhermore, some research has found that skin blood flow relates to diabetes and peripheral vascular disease [13, 14]
We demonstrate our new multifunctional Jones matrix optical coherence tomography (JM-OCT) for dermatological imaging
Summary
Optical coherence tomography (OCT) is a noninvasive, high resolution, and fast imaging modality that is capable of visualizing the internal micro-structures of in vivo tissue [1] Because of these particular advantages, OCT has been applied in several medical fields such as ophthalmology [2, 3], cardiology [4], gastroenterology [5], dentistry [6], and dermatology [7,8,9,10]. Futhermore, some research has found that skin blood flow relates to diabetes and peripheral vascular disease [13, 14] This suggests that non-invasive angiography would be able to provide useful information for diagnosing diabetes and vascular disease
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