Abstract
Collective cell migration occurs in various physiological and pathological processes such as embryonic development, wound healing and tumor invasion. Studies on collective dynamics are crucial for understanding the mechanism underlying collective cell migration and its related biological processes. Here, we propose a three-dimensional (3D) multicellular model based on elastically deformable shells. The equation of motion on the vertices of the cell was established. A 3D collective cell dynamics theory that involves cell deformations and intercellular contact and adhesion is established, and the corresponding numerical algorithm is developed. Based on the developed dynamic model, the rotation of collective cell confined in a spherical lumen is simulated. Our simulations reproduce the experimental observation. Further, we analyze the influence of cell polarity, cell deformations, and intercellular interactions on the 3D dynamics of collective cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
