Three-dimensional assessment of papillary muscle displacement in a porcine model of ischemic mitral regurgitation

Abstract

Papillary muscle displacement relative to mitral annulus is pivotal in chronic functional ischemic mitral regurgitation. Analysis of 3-dimensional papillary muscle displacement has relied on invasive measurement. In this study, we used noninvasive clinically applicable 3-dimensional morphology cardiac magnetic resonance imaging to define papillary muscle position in a 3-dimensional matrix. Fifty pigs (approximately 50 kg) were subjected to posterolateral myocardial infarction and tachycardiac stress. Fourteen animals survived 6 weeks: 10 acquired chronic functional ischemic mitral regurgitation at least grade II and 4 did not. Animals were examined by 3-dimensional morphology cardiac magnetic resonance imaging, and dedicated software enabled assessment of anterior and posterior papillary muscle positions relative to anterior and posterior trigones and posterior mitral annulus. Animals with functional ischemic mitral regurgitation were compared with those without and with 10 healthy controls. Relative to controls, animals with functional ischemic mitral regurgitation at end systole had significantly higher displacements of the posterior papillary muscle from anterior and posterior trigones in lateral and posterior directions, and of anterior papillary muscle from anterior and posterior trigones in apical direction. Relative to animals without functional ischemic mitral regurgitation, there was significantly higher posterior papillary muscle displacement from posterior trigone in lateral direction. Interpapillary muscle distance was the strongest predictor of regurgitant volume (r(2) = 0.85, P < .001). Three-dimensional morphology cardiac magnetic resonance imaging enabled detailed analysis of local left ventricular remodeling effects causing functional ischemic mitral regurgitation.