Abstract
ABSTRACT The studies of early cytologists, well before the turn of this century, indicated that the positions of mitotic chromosomes in a particular metaphase cell correlated with their respective positions in preceding cell divisions. Observations of this type led to the concept that metaphase chromosomes were not simply aggregations of dispersed chromatin. Furthermore, when it became clear that chromosomes were the carriers of the genetic material many ideas developed relating the arrangement of chromosomes to gene expression in nuclei. A major problem in analysing interphase nuclei was the difficulty in visualizing chromosomes at this stage in the cell cycle. Recent advances in combining the techniques of molecular biology with modifications to the optical microscope and computer image enhancement, analysis and interpretation have revolutionized the capability of studying the very old problem of whether order exists within the eukaryote nucleus.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
