Abstract
Pyrano[2,3-d]pyrimidine derivatives were synthesized via one-pot, three-component condensation reaction of aromatic aldehydes, malononitrile, and barbituric acid in aqueous ethanol catalyzed by Ni2+ supported on hydroxyapatite-core–shell-γ-Fe2O3 nanoparticles (γ-Fe2O3@HAp-Ni2+ NPs) as Lewis acid. The nontoxic nature and easy handling of the catalyst, environmentally friendly and facile work-up procedure, short reaction time, low catalyst loading, and high effectiveness to give products in good to excellent yield are advantages of this approach. Also, γ-Fe2O3@HAp-Ni2+ NPs can be easily recovered and reused for at least six runs.
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