Three-component or four-component coupling reactions leading to δ-lactams. Facile synthesis of γ-acyl-δ-lactams from silyl enolates, α,β-unsaturated thioesters, and imines or amines and aldehydes via tandem Michael-imino aldol reactions

Abstract

Various γ-acyl-δ-lactam derivatives were prepared on the basis of three-component (silyl enolates, α,β-unsaturated thioesters, and imines) or four-component (silyl enolates, α,β-unsaturated thioesters, amines, and aldehydes) coupling reactions via Lewis acid-catalyzed tandem Michael-imino aldol reactions.