Abstract
Three different types of changes in membrane conductance were induced in isolated mammalian sympathetic neurons by the muscarinic actions of acetylcholine at different levels of concentration. These include a voltage-independent increase and two decreases, voltage-dependent and -independent, respectively. Muscarinic receptors in sympathetic neurons are thus shown to be coupled to multiple ionic channels, even within a single cell, and controlled by the different concentrations of a neurotransmitter.
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