Abstract
HIV-1 infection stimulates a strong CTL response that coincides with resolution of viremia in acute infection and declines with development of opportunistic infections. Recognition of HIV gp160 by PBMC-derived T cell lines from 20 HIV-infected subjects is dominated by the response to a small number of peptide epitopes. Overlapping CTL epitopes restricted by multiple MHC Class I elements were identified in 3 relatively conserved regions of gp160 (amino acids 49–68, 591–600 and 844–863). CTL from five of 20 subjects recognized three overlapping immunodominant epitopes in the 49–68 a.a. region restricted by A24, B38, and B55. CTL from four subjects recognized at least three distinct epitopes in a.a. 591–600 in the context of A24, B8, B14, and B27. CTL from seven subjects recognized epitopes within a.a. 844–863 restricted by A30, B7, B8 and B35.
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