Abstract
Pulsed drug delivery(PDD),which can be released at well-defined time points as the therapy needs,can decrease the frequency and avoid taking drug at night,thus improving patient compliance.Here we introduce three kinds of programmed PDD systems independent of external chemical triggering;they are divided according to the triggering mechanisms:degradation-triggered PDD,osmotic pressure-triggered PDD,and both degradationi and osmotic pressure-triggered PDD.This paper reviews preparing technique,release mechanisms and influencing factors of the three PDD systems.The release profiles of pulsatile PDD can be regulated for different therapeutic needs,requiring no external triggers;especially that the PDD system triggered by both degradation and osmotic pressure has a bright future.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Academic Journal of Second Military Medical University
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
