Abstract
We have shown previously that a hepatic lipase allele (designated –514T) is common among African Americans and contributes to low hepatic lipase activity in this population. To identify other hepatic lipase alleles associated with low hepatic lipase activity in this population, the coding region and intron–exon boundaries of the hepatic lipase gene were sequenced in 20 African American men with low hepatic lipase activity. Two polymorphisms (N193S and L334F) were associated with low post-heparin plasma hepatic lipase activity and were much more common in African Americans than in whites. This finding, together with our previous data on the –514T allele, indicates that at least three different hepatic lipase polymorphisms associated with low hepatic lipase activity are common among African Americans. Analysis of hepatic lipase haplotypes revealed that 97% of African Americans have at least one hepatic lipase allele that is associated with low hepatic lipase activity.—Nie, L., S. Niu, G. L. Vega, L. T. Clark, A. Tang, S. M. Grundy, and J. C. Cohen. Three polymorphisms associated with low hepatic lipase activity are common in African Americans.
Highlights
We have shown previously that a hepatic lipase allele is common among African Americans and contributes to low hepatic lipase activity in this population
We found that the activity of hepatic lipase, an enzyme involved in HDL catabolism, is lower in African American men than in white American men [5]
The exons and intron/exon boundaries of the hepatic lipase gene were sequenced in 20 African American men who had low post-heparin plasma hepatic lipase activities
Summary
The study was approved by the Institutional Review Boards at the University of Texas Southwestern Medical Center and the State University of New York Health Science Center. White Men n Age BMI (kg/m2) Plasma cholesterol (mg/dl) Plasma triglyceride (mg/dl) HDL-cholesterol (mg/dl)
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