Abstract
THREE pedigrees have been found which are of interest in relation to the two-locus theory of the inheritance of red-green blindness formulated by Waaler1 and Francesehetti2, and summarized by Gates3. The present hypothesis suggests two series of alleles with near loci on the X-chromosome, N, r, r′, p and N′, g, d′, d, in which N and N′ stand for the normal genes, r for red anomaly, r′ for red anomaly with darkened red4, p for protanopia, g for green anomaly, d′ for deviant or anomalous deuter-anopia5, and d for ordinary deuteranopia. The orders of dominance are believed to be as shown above, N and N′ being the most dominant. The two-locus theory is supported by the observation that certain women carrying genes from both series are of normal phenotype1,2,6,7, and the discovery all over the world of fewer women defectives3 than would be expected on the single-locus theory by the calculation given by Ford8.
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