Abstract
Three novel dihydrochalcones, flemilineatins C–E (1–3), and two known flavanones (4–5) were isolated from Flemingia lineata (L.) W.T. Aiton leaves. Dihydrochalcones 1–3 structures were established using NMR spectrum and high-resolution ESIMS data. Compounds 1–5 were assayed to Plasmodium falciparum lactate dehydrogenase (PfLDH) for their antiplasmodial activity. Compounds 2 and 5 exhibited high activity with an IC50 value of 0.74 and 0.79 µg/mL, respectively.
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